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Narcotic and psychoactive substances Psychoactive substances (cocaine, cracked, ecstasy, anfetamine, ephedrine, nicotine, caffeine) cause exaggerated mental and physical activity, inadequate self-confidence, a sense of superiority, later causing irritability, anxiety. Psychoactive substances (poppy extract, heroin, Morphius, promedol, methadone, alcohol, sedatives and hypnotics) cause